Potential common pathogenesis of several neurodegenerative diseases
Ting Fan1
Jiaman Peng1
Huiting Liang2
Wenzhi Chen3
Junlin Wang3
Renshi Xu1
1.Department of Neurology,Jiangxi Provincial People's Hospital;The Clinical College of Nanchang Medical College;The First Affiliated Hospital of Nanchang Medical College;Xiangya Hospital of Center South University,Jiangxi Hospital;National Regional Center for Neurological Disease,Nanchang,Jiangxi Province,China;Medical College of Nanchang University,Nanchang,Jiangxi Province,China2.Department of Neurology,The First Affiliated Hospital of Nanchang University,Nanchang,Jiangxi Province,China3.Department of Neurology,Jiangxi Provincial People's Hospital;The Clinical College of Nanchang Medical College;The First Affiliated Hospital of Nanchang Medical College;Xiangya Hospital of Center South University,Jiangxi Hospital;National Regional Center for Neurological Disease,Nanchang,Jiangxi Province,China
摘要：With the gradual advancement of research methods and technologies,various biological processes have been identified as playing roles in the pathogenesis of neurodegenerative diseases.However,current descriptions of these biological processes do not fully explain the onset,progression,and development of these conditions.Therefore,exploration of the pathogenesis of neurodegenerative diseases remains a valuable area of research.This review summarizes the potential common pathogeneses of Alzheimer's disease,Parkinson's disease,amyotrophic lateral sclerosis,Huntington's disease,frontotemporal lobar dementia,and Lewy body disease.Research findings have indicated that several common biological processes,including aging,genetic factors,progressive neuronal dysfunction,neuronal death and apoptosis,protein misfolding and aggregation,neuroinflammation,mitochondrial dysfunction,axonal transport defects,and gut microbiota dysbiosis,are involved in the pathogenesis of these six neurodegenerative diseases.Based on current information derived from diverse areas of research,these biological processes may form complex pathogenic networks that lead to distinctive types of neuronal death in neurodegenerative diseases.Furthermore,promoting the regeneration of damaged neurons may be achievable through the repair of affected neural cells if the underlying pathogenesis can be prevented or reversed.Hence,these potential common biological processes may represent only very small,limited elements within numerous intricate pathogenic networks associated with neurodegenerative diseases.In clinical treatment,interfering with any single biological process has proven insufficient to completely halt the progression of neurodegenerative diseases.Therefore,future research on the pathogenesis of neurodegenerative diseases should focus on uncovering the complex pathogenic networks,rather than isolating individual biological processes.Based on this,therapies that aim to block or reverse various targets involved in the potential pathogenic mechanisms of neurodegenerative diseases may be promising directions,as current treatment methods that focus on halting a single pathogenic factor have not achieved satisfactory efficacy.
机标关键词：neurodcommondegenerativediseasespathogenesispotentialseveral
论文发表日期：2026-03-30
在线出版日期：2026-03-18（本平台首次上网日期，不代表文献的发表时间）
页数：17( 972-988 )
英文信息