Lysophosphatidic acid signaling:Transmembrane modulators in the central nervous system
Alexandra Polyzou1
Alexandros K.Tsiouris1
Charalampos Labrakakis2
Britta J.Eickholt3
George Leondaritis4
1.Department of Pharmacology,Faculty of Medicine,School of Health Sciences,University of Ioannina,Ioannina,Greece2.Department of Biological Applications and Technology,School of Health Sciences,University of Ioannina,Ioannina,Greece;Institute of Biosciences,University Research Center of Ioannina(URCI),Ioannina,Greece3.Institute for Molecular Biology and Biochemistry,CharitéUniversitäsmedizin Berlin,Berlin,Germany4.Department of Pharmacology,Faculty of Medicine,School of Health Sciences,University of Ioannina,Ioannina,Greece;Institute of Biosciences,University Research Center of Ioannina(URCI),Ioannina,Greece
摘要：Lysophosphatidic acid (LPA) is a pleiotropic lipid agonist essential for functions of the central nervous system (CNS). It is abundant in the developing and adult brain while its concentration in biological fluids,including cerebrospinal fluid,varies significantly (Figure 1Α;Yung et al.,2014).LPA actually corresponds to a variety of lipid species that include different stereoisomers with either saturated or unsaturated fatty acids bearing likely differentiated biological activities (Figure 1Α;Yung et al.,2014;Hernández-Araiza et al.,2018). During CNS development,LPA influences critical processes such as cell proliferation,survival,and differentiation,promotes neuronal migration,and affects neuronal morphology(Yung et al.,2014). Furthermore,LPA mediates cortical development,myelination,pain,synaptic transmission,and plasticity (Yung et al.,2014).Deregulation of LPA signaling contributes to a myriad of CNS pathologies including psychiatric diseases,neurodegeneration,neuropathic pain,neuroinflammatory,and traumatic conditions(Yung et al.,2014).
机标关键词：centrallysosystemphatacidphosmodulatorsnervous
论文发表日期：2026-03-30
在线出版日期：2026-03-18（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1104-1105 )