Cell Phf8[ˈfeɪt]control:Epigenetic regulation during oligodendroglial development
Marco Kremp
Michael Wegner
Institut für Biochemie,Friedrich-Alexander-Universität Erlangen-Nürnberg,Erlangen,Germany
摘要：Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes (OLs) are the myelinating glial cells of the vertebrate central nervous system. They are responsible for insulating neuronal axons with a lipid-rich myelin sheath,which enables the saltatory conduction of action potentials.During development,oligodendrocyte progenitor cells (OPCs) emerge from neural stem cells in the ventricular zone. They then proliferate,increase their number,and migrate to their final destination where they encounter unmyelinated neuronal axons and differentiate in a stepwise fashion into myelinating oligodendrocytes (mOLs) under the influence of environmental stimuli.
机标关键词：developmentcontrollialcellduringepigeneticoligodendrogliaregulation
论文发表日期：2026-03-30
在线出版日期：2026-03-18（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1110-1111 )