Morphological characteristics and corresponding functional properties of homeostatic human microglia
Pariya Khodabakhsh
Olga Garaschuk
Institute of Physiology,Department of Neurophysiology,Eberhard Karls University of Tübingen,Tübingen,Germany
摘要：Microglia,the resident immune cells of the central nervous system,exhibit a wide array of functional states,even in their so-called "homeostatic"condition,when they are not actively responding to overt pathological stimuli. These functional states can be visualized using a combination of multi-omics techniques (e.g.,gene and protein expression,posttranslational modifications,mRNA profiling,and metabolomics),and,in the case of homeostatic microglia,are largely defined by the global (e.g.,genetic variations,organism's age,sex,circadian rhythms,and gut microbiota) as well as local (specific area of the brain,immediate microglial surrounding,neuron-glia interactions and synaptic density/activity) signals (Paolicelli et al.,2022). While phenomics (i.e.,ultrastructural microglial morphology and motility) is also one of the key microglial state-defining parameters,it is known that cells with similar morphology can belong to different functional states.
机标关键词：characteristicsmorphologicalhumancorrespondingfunctionalhomeostaticmicrogliaproperties
论文发表日期：2026-03-30
在线出版日期：2026-03-18（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1112-1113 )