Metformin remodels the myelin landscape
Bandy Chen
Department of Medicine,UC San Diego School of Medicine,La Jolla,CA,USA
摘要：The rapidly aging population directly contributes to the increasing cases of neurological disorders.Due to the chronic progressive nature of neurodegeneration,numerous neurological conditions are considered "multifactorial" with systemic metabolic alterations. Even so,treatments for neurological disorders have remained unchanged for the past decades. Recently,metabolic drugs such as metformin and glucagon-like peptide 1 agonists have demonstrated promising health outcomes for neurodegeneration.While the exact mechanisms remain to be elucidated,this promotes the repurposing of antidiabetic drugs for cognitive health and redefines neurological disorders as "neurometabolic"disorders. The complexity of systemically acting drugs lies in determining whether their effects are mediated directly through their actions on the brain or indirectly via their peripheral effects.This perspective focuses on the repurposing of metformin for neurological disorders through the remodeling of the myelin landscape.
机标关键词：landscapemetforminmyelinremodels
论文发表日期：2026-03-30
在线出版日期：2026-03-18（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1120-1121 )