Dysregulated insulin signaling and inflammation contribute to the pathogenesis of Alzheimer's disease:From animal models to human cells
Marcus Elo Rytter1
Cecilie Amalie Brøgger Svane1
Joachim Størling2
Wenqiang Chen3
1.Steno Diabetes Center Copenhagen,Herlev,Denmark2.Steno Diabetes Center Copenhagen,Herlev,Denmark;Department of Biomedical Sciences,University of Copenhagen,Copenhagen,Denmark3.Steno Diabetes Center Copenhagen,Herlev,Denmark;Joslin Diabetes Center,Harvard Medical School,Boston,MA,USA
摘要：The shared links between Alzheimer's disease and type 2 diabetes mellitus:Alzheimer's disease(AD) and type 2 diabetes mellitus (T2DM) are two prevalent conditions that come with substantial daily struggles. Emerging evidence highlights that these diseases share similar pathophysiological features,including insulin resistance and chronic inflammation,which contribute to their rapid progression (Chen et al.,2022). Insulin resistance,a hallmark of T2DM,has been suggested to exacerbate neurodegeneration in AD. Similarly,chronic low-grade inflammation in T2DM parallels with neuroinflammation,which is observed in AD,suggesting overlapping pathophysiological mechanisms in T2DM and AD.
机标关键词：alzheimerinsulinhumanmodelscellsfromanimalcontribute
论文发表日期：2026-03-30
在线出版日期：2026-03-18（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1126-1127 )