Plasticity meets regeneration during innate spinal cord repair
Amruta Tendolkar1
Mayssa H.Mokalled2
1.Department of Developmental Biology,Washington University School of Medicine,Saint Louis,MO,USA2.Department of Developmental Biology,Washington University School of Medicine,Saint Louis,MO,USA;Center of Regenerative Medicine,Washington University School of Medicine,Saint Louis,MO,USA;Hope Center for Neurological Disorders,Washington University School of Medicine,Saint Louis,MO,USA
摘要：Regenerative capacity of the central nervous system(CNS) is unevenly distributed among vertebrates.While most mammalian species including humans elicit limited repair following CNS injury or disease,highly regenerative vertebrates including urodele amphibians and teleost fish spontaneously reverse CNS damage.Teletost zebrafish (danio rerio) are tropical freshwater fish that proved to be an excellent vertebrate model of successful CNS regeneration. Differential neuronal,glial,and immune injury responses underlie disparate injury outcomes between highly regenerative zebrafish and poorly regenerative mammals. This article describes complications associated with neuronal repair following spinal cord injury (SCI) in poorly regenerative mammals and highlights intersecting modes of plasticity and regeneration in highly regenerative zebrafish (Figures 1 and 2). Comparative approaches evaluating immunoglial SCI responses were recently reviewed elsewhere (Reyes and Mokalled,2024).
机标关键词：regenerationcordduringinnatemeetsplasticityrepairspinal
论文发表日期：2026-03-30
在线出版日期：2026-03-18（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1136-1137 )