Pericyte-glial cell interactions:Insights into brain health and disease
Ali Sepehrinezhad1
Ali Gorji2
1.Neuroscience Research Center,Mashhad University of Medical Sciences,Mashhad,Iran;Department of Neuroscience,Faculty of Medicine,Mashhad University of Medical Sciences,Mashhad,Iran2.Neuroscience Research Center,Mashhad University of Medical Sciences,Mashhad,Iran;Department of Neuroscience,Faculty of Medicine,Mashhad University of Medical Sciences,Mashhad,Iran;Shefa Neuroscience Research Center,Khatam Alanbia Hospital,Tehran,Iran;Epilepsy Research Center,Münster University,Münster,Germany;Department of Neurosurgery,Münster University,Münster,Germany
摘要：Pericytes are multi-functional mural cells of the central nervous system that cover the capillary endothelial cells.Pericytes play a vital role in nervous system development,significantly influencing the formation,maturation,and maintenance of the central nervous system.An expanding body of studies has revealed that pericytes establish carefully regulated interactions with oligodendrocytes,microglia,and astrocytes.These communications govern numerous critical brain processes,including angiogenesis,neurovascular unit homeostasis,blood-brain barrier integrity,cerebral blood flow regulation,and immune response initiation.Glial cells and pericytes participate in dynamic and reciprocal interactions,with each influencing and adjusting the functionality of the other.Pericytes have the ability to control astrocyte polarization,trigger differentiation of oligodendrocyte precursor cells,and initiate immunological responses in microglia.Various neurological disorders that compromise the integrity of the blood-brain barrier can disrupt these communications,impair waste clearance,and hinder cerebral blood circulation,contributing to neuroinflammation.In the context of neurodegeneration,these disruptions exacerbate pathological processes,such as neuronal damage,synaptic dysfunction,and impaired tissue repair.This article explores the complex interactions between pericytes and various glial cells in both healthy and pathological states of the central nervous system.It highlights their essential roles in neurovascular function and disease progression,providing important insights that may enhance our understanding of the molecular mechanisms underlying these interactions and guide potential therapeutic strategies for neurodegenerative disorders in future research.
机标关键词：insightsbraincelldiseasehealthinteractionsintopericyte-glial
论文发表日期：2026-04-30
在线出版日期：2026-03-25（本平台首次上网日期，不代表文献的发表时间）
页数：11( 1253-1263 )
英文信息