Inherent potential of mitochondria-targeted interventions for chronic neurodegenerative diseases
Min Zhou1
Min Zheng1
Siyao Liang1
Maomao Li1
Jiarui Ma1
Shiyu Zhang1
Xinyao Song1
Yonglin Hu2
Yuhong Lyu1
Xingkun Ou2
Changwu Yue3
1.Yan'an Key Laboratory of Microbial Drug Innovation and Transformation,Yan'an Medical College of Yan'an University,Yan'an,Shaanxi Province,China2.Department of Laboratory Medicine,Kweichow Moutai Hospital,Zunyi,Guizhou Province,China3.Yan'an Key Laboratory of Microbial Drug Innovation and Transformation,Yan'an Medical College of Yan'an University,Yan'an,Shaanxi Province,China;Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources,Yan'an University,Yan'an,Shaanxi Province,China
摘要：The cure rate for chronic neurodegenerative diseases remains low,creating an urgent need for improved intervention methods.Recent studies have shown that enhancing mitochondrial function can mitigate the effects of these diseases.This paper comprehensively reviews the relationship between mitochondrial dysfunction and chronic neurodegenerative diseases,aiming to uncover the potential use of targeted mitochondrial interventions as viable therapeutic options.We detail five targeted mitochondrial intervention strategies for chronic neurodegenerative diseases that act by promoting mitophagy,inhibiting mitochondrial fission,enhancing mitochondrial biogenesis,applying mitochondria-targeting antioxidants,and transplanting mitochondria.Each method has unique advantages and potential limitations,making them suitable for various therapeutic situations.Therapies that promote mitophagy or inhibit mitochondrial fission could be particularly effective in slowing disease progression,especially in the early stages.In contrast,those that enhance mitochondrial biogenesis and apply mitochondria-targeting antioxidants may offer great benefits during the middle stages of the disease by improving cellular antioxidant capacity and energy metabolism.Mitochondrial transplantation,while still experimental,holds great promise for restoring the function of damaged cells.Future research should focus on exploring the mechanisms and effects of these intervention strategies,particularly regarding their safety and efficacy in clinical settings.Additionally,the development of innovative mitochondria-targeting approaches,such as gene editing and nanotechnology,may provide new solutions for treating chronic neurodegenerative diseases.Implementing combined therapeutic strategies that integrate multiple intervention methods could also enhance treatment outcomes.
机标关键词：neurodchronicdegenerativediseasesinherentinterventionsmitochondriapotential
论文发表日期：2026-04-30
在线出版日期：2026-03-25（本平台首次上网日期，不代表文献的发表时间）
页数：19( 1409-1427 )
英文信息