Potential targets of microglia in the treatment of neurodegenerative diseases:Mechanism and therapeutic implications
Wenhui Zhao1
Zhongxuan Liu2
Jiannan Wu1
Anran Liu1
Junqiang Yan3
1.Neuromolecular Biology Laboratory,The First Affiliated Hospital,College of Clinical Medicine of Henan University of Science and Technology,Luoyang,Henan Province,China2.Department of Rehabilitation,The First People's Hospital of Zhengzhou,Zhengzhou,Henan Province3.Neuromolecular Biology Laboratory,The First Affiliated Hospital,College of Clinical Medicine of Henan University of Science and Technology,Luoyang,Henan Province,China;Department of Neurology,The First Affiliated Hospital,College of Clinical Medicine of Henan University of Science and Technology,Luoyang,Henan Province,China
摘要：For diverse neurodegenerative disorders,microglial cells are activated.Furthermore,dysfunctional and hyperactivated microglia initiate mitochondrial autophagy,oxidative stress,and pathological protein accumulation,ending with neuroinflammation that exacerbates damage to dopaminergic neurons and contributes significantly to the pathology of neurodegenerative disorder.Microglial over-activation is closely associated with the secretion of pro-inflammatory cytokines,the phagocytosis of injured neurons,and the modulation of neurotoxic environments.This review summarizes the role of microglia neurodegenerative diseases,such as Alzheimer's disease,Parkinson's disease,multiple sclerosis,multiple system atrophy,amyotrophic lateral sclerosis,frontotemporal dementia,progressive supranuclear palsy,cortical degeneration,Lewy body dementia,and Huntington's disease.It also discusses novel forms of cell death such as ferroptosis,cuproptosis,disulfidptosis,and parthanatos(poly(adenosine diphosphate ribose)polymerase 1-dependent cell death),as well as the impact of regulatory factors related to microglial inflammation on microglial activation and neuroinflammation.The aim is to identify potential targets for microglial cell therapy in neurodegenerative diseases.
机标关键词：mechanismneuroddegenerativediseasesimplicationsmicrogliapotentialtargets
论文发表日期：2026-04-30
在线出版日期：2026-03-25（本平台首次上网日期，不代表文献的发表时间）
页数：15( 1497-1511 )
英文信息