Noradrenergic excitation of astrocytes supports cognitive reserve
Robert Zorec1
Alexei Verkhratsky2
1.Laboratory of Neuroendocrinology and Molecular Cell Physiology,Institute of Pathophysiology,University of Ljubljana,Ljubljana,Slovenia;Celica Biomedical,Technology Park,Ljubljana,Slovenia2.Laboratory of Neuroendocrinology and Molecular Cell Physiology,Institute of Pathophysiology,University of Ljubljana,Ljubljana,Slovenia;Celica Biomedical,Technology Park,Ljubljana,Slovenia;Faculty of Biology,Medicine and Health,The University of Manchester,Manchester,UK;Department of Neurosciences,University of the Basque Country,Leioa,Bizkaia,Spain and IKERBASQUE Basque Foundation for Science,Bilbao,Spain
摘要：The concept of the brain cognitive reserve is derived from the well-acknowledged notion that the degree of brain damage does not always match the severity of clinical symptoms and neurological/cognitive outcomes.It has been suggested that the size of the brain(brain reserve)and the extent of neural connections acquired through life(neural reserve)set a threshold beyond which noticeable impairments occur.In contrast,cognitive reserve refers to the brain's ability to adapt and reorganize structurally and functionally to resist damage and maintain function,including neural reserve and brain maintenance,resilience,and compensation(Verkhratsky and Zorec,2024).
机标关键词：cognitiveastrocytesexcitationnoradrenergicreservesupports
论文发表日期：2026-04-30
在线出版日期：2026-03-25（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1546-1547 )