Chromatin accessibility regulates axon regeneration
Isa Samad
Brett J.Hilton
Department of Cellular and Physiological Sciences,Faculty of Medicine,University of British Columbia,Vancouver,BC,Canada;International Collaboration on Repair Discoveries(ICORD),University of British Columbia,Vancouver,BC,Canada;Djavad Mowafaghian Centre for Brain Health,University of British Columbia,Vancouver,BC,Canada
摘要：Central nervous system(CNS)axons fail to regenerate following brain or spinal cord injury(SCI),which typically leads to permanent neurological deficits.Peripheral nervous system axons,however,can regenerate following injury.Understanding the mechanisms that underlie this difference is key to developing treatments for CNS neurological diseases and injuries characterized by axonal damage.To initiate repair after peripheral nerve injury,dorsal root ganglion(DRG)neurons mobilize a pro-regenerative gene expression program,which facilitates axon outgrowth.Chromatin accessibility actively regulates this genetic program by controlling how easily transcriptional machinery can bind to DNA(Palmisano et al.,2019;Cheng et al.,2023).
机标关键词：accessibilityregenerationaxonchromatinregulates
论文发表日期：2026-04-30
在线出版日期：2026-03-25（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1548-1549 )