mTORC1 and mTORC2 synergy in human neural development,disease,and regeneration
Navroop K.Dhaliwal1
Julien Muffat2
Yun Li3
1.Program in Developmental and Stem Cell Biology,The Hospital for Sick Children,Toronto,ON,Canada2.Program in Neurosciences and Mental Health,The Hospital for Sick Children,Toronto,ON,Canada;Department of Molecular Genetics,University of Toronto,Toronto,ON,Canada3.Program in Developmental and Stem Cell Biology,The Hospital for Sick Children,Toronto,ON,Canada;Department of Molecular Genetics,University of Toronto,Toronto,ON,Canada
摘要：The mechanistic target of rapamycin(mTOR)is a serine/threonine kinase that plays a pivotal role in cellular growth,proliferation,survival,and metabolism.In the central nervous system(CNS),the mTOR pathway regulates diverse aspects of neural development and function.Genetic mutations within the mTOR pathway lead to severe neurodevelopmental disorders,collectively known as"mTORopathies"(Crino,2020).Dysfunctions of mTOR,including both its hyperactivation and hypoactivation,have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions,highlighting its importance in CNS health.Molecularly,mTOR functions as the catalytic subunit of two distinct complexes:mTOR complex 1(mTORC1)and mTOR complex 2(mTORC2).These two complexes are defined by their unique components and substrate specificities,which in turn activate distinct downstream signaling cascades that underpin their diverse roles in the CNS.mTORC1,characterized by the presence of RPTOR(Regulatory Associated Protein of MTOR complex 1),is known to govern protein synthesis and autophagy.In contrast,mTORC2,which contains RICTOR(RPTOR Independent Companion of MTOR complex 2),is less understood but is known to regulate the actin cytoskeleton and metabolism.
机标关键词：developmentregenerationmtorc2mtorc1humandiseaseneuralsynergy
论文发表日期：2026-04-30
在线出版日期：2026-03-25（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1552-1553 )