Immunoproteasome as a therapeutic target in obesity-related brain inflammation and metabolic disorders
Javiera Álvarez-Indo1
Nicolás Albornoz1
Andrea Soza2
Patricia V.Burgos2
1.Centro de Biología Celular y Biomedicina,Facultad de Medicina y Ciencia,Universidad San Sebastián,Santiago,Chile2.Centro de Biología Celular y Biomedicina,Facultad de Medicina y Ciencia,Universidad San Sebastián,Santiago,Chile;Centro Basal Ciencia & Vida,Universidad San Sebastián,Santiago,Chile
摘要：Obesity is widely recognized as a global epidemic,primarily driven by an imbalance between energy expenditure and caloric intake associated with a sedentary lifestyle.Diets high in carbohydrates and saturated fats,particularly palmitic acid,are potent inducers of chronic low-grade inflammation,largely due to disruptions in glucose metabolism and the onset of insulin resistance(Qiu et al.,2022).While many organs are affected,the brain,specifically the hypothalamus,is among the first to exhibit inflammation in response to an unhealthy diet,suggesting that obesity may,in fact,be a brain-centered disease with neuroinflammation as a central factor(Thaler et al.,2012).
机标关键词：metabolictargetbraindisordersinflammationobesity-relatedproteasometherapeutic
论文发表日期：2026-04-30
在线出版日期：2026-03-25（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1554-1555 )