Melatonin and mitochondrial stress:New insights into age-related neurodegeneration
Silvia Carloni1
Francesca Luchetti1
Maria Gemma Nasoni1
Walter Balduini1
Walter Manucha2
Russel J.Reiter3
1.Department of Biomolecular Sciences,University of Urbino Carlo Bo,Urbino,Italy2.Instituto de Medicina y Biologia Experimental de Cuyo(IMBECU),Consejo Nacional de Investigaciones Cientificas y Tecnologicas(CONICET),Mendoza,Argentina3.Department of Cell Systems and Anatomy,UT Health San Antonio,Long School of Medicine,San Antonio,TX,USA
摘要：Aging,mitochondria,and neurodegenerative diseases:Aging is often viewed as the buildup of changes that lead to the gradual transformations associated with getting older,along with a rising likelihood of disease and mortality.Although organism-wide deterioration is observed during aging,organs with high metabolic demand,such as the brain,are more vulnerable.Consequently,most neurodegenerative diseases occur in the aged population.Even in the healthy brain,the normal aging process is associated with several features of the neurodegenerative process,including neuroinflammation,and brain shrinkage,with a progressive decline in physiological functions(Lee and Kim,2022).
机标关键词：melatonininsightsneurodstressage-relateddegenerationintomitochondrial
论文发表日期：2026-04-30
在线出版日期：2026-03-25（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1564-1565 )