Determinants of alpha-synuclein pathogenesis in Parkinson's disease
Oriol Bárcenas
Marc Estivill-Alonso
Salvador Ventura
Institut de Biotecnologia i Biomedicina,Universitat Autònoma de Barcelona,Bellaterra,Spain;Departament de Bioquímica i Biologia Molecular,Universitat Autònoma de Barcelona,Bellaterra,Spain;Hospital Universitari ParcTaulí,Institut d'Investigació i Innovació ParcTaulí(I3PT-CERCA),Universitat Autònoma de Barcelona,Sabadell,Spain
摘要：Alpha-synuclein and Parkinson's disease:Neuronal damage and inflammation caused by the aggregation of alpha-synuclein(α-syn)are central to a group of disorders known as synucleopathies,which includes Parkinson's disease(PD),dementia with Lewy bodies,and multiple system atrophy,among others.PD,the most common synucleinopathy,is the second most prevalent neurodegenerative disease after Alzheimer's disease,and it is the fastest growing.Its primary hallmark is the degeneration of dopaminergic neurons in the substantia nigra pars compacta,disrupting the communication with the striatum.This has adverse motor and nonmotor effects,with the most prominent symptoms being tremors,rigidity,instability,and gait difficulties.While most patients have a late onset(60+years),certain dominant genetic mutations in the gene encoding α-syn are associated with earlier onset.Despite the severity and prevalence of the disease,no treatments that halt or modify the pathology progression exist,with available therapies providing only symptomatic relief for motor symptoms(Vázquez-Vélez and Zoghbi,2021).
机标关键词：parkinsonalpha-synucleindeterminantsdiseasepathogenesis
论文发表日期：2026-04-30
在线出版日期：2026-03-25（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1568-1569 )