Efferocytosis and retinal clean-up:Role of histone deacetylase 3 in ischemic retinopathy
Abdelrahman Y.Fouda
Esraa Shosha
Department of Pharmacology and Toxicology,College of Medicine,University of Arkansas for Medical Sciences,Little Rock,AR,USA;Department of Clinical Pharmacy,Faculty of Pharmacy,Cairo University,Cairo,Egypt
摘要：Ischemic retinopathy is a leading cause of blindness:Ischemic retinopathies including diabetic retinopathy(DR),retinopathy of prematurity,and retinal artery and vein occlusion are major causes of visual impairment.Ischemic retinopathy can be acute,such as in central or branch retinal artery occlusion,or chronic,such as with DR(Figure 1).Although the causes of retinopathies are diverse,one pathogenic event shared by these conditions is the myeloid cell response to retinal ischemia(Shahror et al.,2024a).The ischemia-induced neurovascular injury results in progressive cell death by apoptosis,causing neurodegeneration and loss of vascular cells.Concurrently,there is activation and proliferation of microglia,non-parenchymal macrophages(such as perivascular macrophages),and recruitment of blood-borne(infiltrating)monocytes.These activated cells(collectively termed"myeloid cells")play either a protective or deleterious role after retinal injury depending on their molecular profile and activation state.
机标关键词：roleclean-updeacetylaseefferocytosishistoneischemicretinalretinopathy
论文发表日期：2026-04-30
在线出版日期：2026-03-25（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1572-1573 )