Novel PLA/Chitosan Composite Materials Prepared by SCF-CO2 Technique
LI LH
ZHANG R
ZHOU CR
摘要：Because of the incomparable merits (nontoxicity, non-remainder,fast transfer mass) of supercritical carbon dioxide fluid technique(SC-CO2), it was used to developed a series of novel biodegradable tissue engineering scaffold materials in this research. The novel PLA/chitosan composite materials could be molded to different shapes, and the porosity of the materials were over 200 μm and connected. Chondrocyte cultivation, subcutaneous and intramuscular implantation were mainly discussed this paper. The results showed that the cells could well adhere,grow and multiplicate on the surface of the materials, which indicated good biocompatibility of the composite materials. The plantation test revealed that the PLA materials had already dismissed 2 month late in the body, while the composite materials could still keep certain strength and shape, and the most important things is the response of the tissue toward the implanted PLA/chitosan composite materials was mild and had far less inflammation than PLA materials. 8 to 16 weeks later, fiber membrane was stable; degradation of the materials was seen clear and tissue had already spread into it.
机标关键词：composite materialssupercritical carbon dioxidetissue engineering scaffold
分类号：R3(基础医学)
资助基金：国家重点基础研究发展计划(973计划)(G1999054306)国家高技术研究发展计划(863计划)(2001AA625050)Guangdong Science and technology bureau(A302020104)
论文发表日期：2005-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 85-92 )
英文信息