Study on Tat Mediated Magnetic Nanoparticles Having Composite Targeting Function
YAO Peng
HUANG Jie
ZHAO Ai-jie
KANG Chun-sheng
CHANG Jin
PU Pei-yu
摘要：This paper describes a new formulation of magnetic nanoparticles coated by a novel polymer matrix-O-Carboxylmethylated Chitosan (O-CMC) as a drug/gene carrier. The O-CMC magnetic nanoparticles were derivatized with a peptide sequence from the HIV-tat protein and transferrin to improve the translocationai property and cellar uptake of the nanoparticles. To evaluate the O-MNPsTat-Tf as a drug carrier, Methotrexate (MTX) was incorporated as a model drug and MTX-Ioaded O-MNPs-Tat-Tf with an average diameter of 75 nm were prepared and characterized by TEM, AFM and VSM. The cytotoxicity of MTX-Ioaded OMNPs-Tat-Tf was investigated with C6 cells. The results showed that the MTXloaded O-MNPs-Tat-Tf retained significant antitumor toxicity.
机标关键词：magnetic nanoparticlesdrug carrier
分类号：R3(基础医学)
资助基金：中国科学院资助项目(50373033)Tianjin Key Research Foundation(YFJZJC01001)
论文发表日期：2005-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 150-155 )
英文信息