Study on Different Modification Methods of Collagen for Tissue Engineering
XU Xin-yu
摘要：Because of the excellent biocompatibility and its specific amino sequences, collagen is an ideal biomedical material for tissue engineering applications. But collagen is usually lack of mechanical strength to form a rigid 3-D matrix and lack of ability to resist collagenase. In order to be a tissue engineering scaffold, collagen must strengthen its structures by modifying with chemical crosslinkers. Chemical crosslinkers used for modif-ying collagen fibers include glutaraldehyde (GA), epoxy compounds (PC) and carbodiim-ides (EDC). The aim of this study is to choose the best chemical crosslinker from the three reagents. In terms of the resistance to collagenase degradation, chemical cross-link-ing with PC provided the best protection; in terms of the mechanical characterization, chemical cross-linking with GA provided the best;and in terms of the biocompatibility, chemical cross-linking with EDC provided the best. There is not a reagent which has all merits for collagen crosslinking, so we should select the crosslinking reagent as the de-mands of use ask.
机标关键词：Tissue Engineeringtissue engineering scaffoldengineering applicationsmechanical strengthbiomedical materialcollagen fibers
分类号：R318.08(医用一般科学)
论文发表日期：2008-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 139-145 )
英文信息