Research on the Construction of Tissue Engineering Scaffolds by Alginate-hyaluronic Acid with Different Characteristics
LI Qin-hua
LIU Li
LIN Dong-qing
摘要：This research uses alginate and hyaluronic acid as the main component to prepare support, then explores the possibilities as a tissue engineering scaffold. Firstly, prepare HA with various average molecular weight and alginate with different viscosity, mix them up at a certain proportion and make it into a AlgCa 2+-HA composite scaffold with a film-forming method. This article discusses the feasibility of this scaffold used in tissue engineering field according to the consequence of moisture content testing, mechanical analysis, and scanning electron microscopy analysis. The structure and properties of AlgCa2+-HA composite scaffold are closely related to some factors such as average molecular weight of hyaluronic acid, hyaluronic acid concentration, alginate viscosity, cross-linking agents and processing technology. The AlgCa 2+-HA composite material, which is at different proportions and adding different cross-linking agent,has some certain characteristics:moisture content ranging from 50%to 95%, tensile strength between 2.69 N/mm2 and 4.299 N/mm2, and elongation at break is about 58%to 160%. The prepared AlgCa2+-HA composite scaffolds can be used as tissue engineering scaffolds resulting from its high moisture content, good mechanical properties and ideal pore structure.
机标关键词：Different Characteristicstissue engineering scaffoldhigh moisture contentaverage molecular weighthyaluronic acidscanning electron microscopystructure and propertiesprocessing technology
分类号：R318.08(医用一般科学)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 101-107 )
英文信息