Parasporal Proteins from Bacillus thuringiensis and Their Cytotoxicity on Human Cancer Cells
WANG Lei
LV Yuan
YI Yin-sha
YI Shang-hui
LI Lin
摘要：Parasporins(PSs) represent a novel functional category of crystal proteins (Cry) produced by non-insecticidal Bacillus thuringiensisA distinct feature for PSs is their specific cytotoxicity against human cancer cells from diverse origins, other than hemolytic or insecticidal activityAs structurally/functionally Cry proteins, parasporins are expressed as protoxins that require protease cleavage for activationCurrently, identified PSs is classified into 6 groups:PS1, PS2, PS3, PS4, PS5 and PS6, which are heterogeneous in cytotoxic spectrum and activity levelSome PSs have been explored for their mode of anticancer activities, reports mainly include pore formation induced by binding to putative receptors on cell membrane and apoptosis by intracellular Ca 2+concentrationFurther work should focus on the identification of new PS or PS homologs and better understanding of their anticancer mechanism before possible application in cancer therapy.
机标关键词：specific cytotoxicityanticancer activitiesidentification ofpore formationcancer therapycell membranemode of
分类号：Q518.3(蛋白质)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 17-27 )
英文信息