A Novel Synthetic Analogue of Curcumin, B7, Inhibits Inflammatory Factors Expression in H2O2 Induced Endothelial Cells
WEI Dang-heng
LIU Yang-hui
JIA Xiao-ying
GUO Feng-xia
WU Jiang-zhang
摘要： Curcumin, a dietary phytochemical, exhibits multifunctional natural product with regulatory effects on inflammation. However, the poor bioavailability limits its clinical applications. Thus, we designed and synthesized a novel monocarbonyl analogue of curcumin B7 and their inhibition against monocyte chemotactic protein-1 (MCP-1) and interleukin-8(IL-8) release was evaluated in H 2O2-stimulated human vascular endothelial cells (ECs) in a dose-responsive manner, while exhibiting no cytotoxicity in ECs. Taken together, these insights on the novel compound B7 may serve as potential agents for the treatment of atherosclerosis.
机标关键词：Endothelial Cellsvascular endothelial cellsnatural product
分类号：O629.1(有机化学)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 93-98 )
英文信息