Clinical Observation on the Effects of Different Doses of Tramadol lnjection for Preemptive Analgesia in Gynaecological Laparoscopy

YAO Qun; YAO Li

摘要：Objective: To observe the analgesic effects of tramadol in general anaesthesia for laparoscopic surgery. Methods: To operate 80 laparoscopic surgeries under the circumstance of general anaesthesia. Randomly divide them into 4 groups, with 20 cases in each group and the intravenous injection should be finished before the operation. Group Ⅰ:2 ml normal saline;Group Ⅱ:1.5 ml/kg tramadol;Group Ⅲ:2 mg/kg tramadol;GroupⅣ:2.5 mg/kg tramadol. Use VAS and Ramsay sedation marking system to assess the degree of pain-feeling and sedation in these circumstances: after pulling out oxygen hose, before leaving the operation room and 1, 2, 4, 8, 12, 24 h after the operation. Meanwhile, record such side effects as nausea, vomiting, dizziness, hypersomnia, restless, nightmares, itchy and sweating. Results: The VAS score was significantly lower within postoperative 8 h in Group Ⅱ,Ⅲ and Ⅳ than that in Group Ⅰ, while no significant difference was found among Group Ⅱ, Ⅲ and Ⅳ at each time point. The postoperative Ramsay sedation score was 0-2 in each group. Incidence of postoperative nausea, vomiting, and sweating were more in Group Ⅱ, Ⅲ and Ⅳ than that in Group Ⅰ. Group Ⅳ and Group Ⅰ have statistical differences, in which P<0.05 or P<0.01. However, Group Ⅱ,Ⅲ and Group Ⅳ have no statistical differences. Conclusion:The study suggests that preoperative injection of 1.5-2 mg/kg tramadol provides satisfactory preoperative analgesia in patients undergoing gynaecological laparoscopy, reducing the use of analgesics and the incidence of side effects.