Motif Discovery and Phylogenetic Analysis of Hepatitis B Virus Sequences
ZHANG Qi
ZHANG Jun-peng
GAO Jian-mei
HE Jian-feng
YAN Xin-min
MA Lei
LI Jiu-yong
摘要：Hepatitis B virus (HBV ) infection is a severe global health problem. In recent years, mutations as an essential element in the HBV evolution have been exten-sively studied. However, the study of the conserved sequence for the evolution of HBV is still in its infancy. In this paper, we applied MEME (multiple EM for motif elicitation) algorithm for motif discovery and proposed a new metric CI (conserved index) to make phylogenetic analysis of HBV sequences. Our results indicate that MEME can efficiently discover multiple motifs from HBV sequences and the new measurement CI for the conservative of sequences can effectively help us to build the phylogenetic tree. Thus, we can get evolutionary relationship of HBV sequence through the phylogenetic tree.
机标关键词：Hepatitis B Virusphylogenetic treephylogenetic analysisglobal health
分类号：R512.6(传染病)
论文发表日期：2016-01-01
页数：6( 121-126 )
英文信息