Immunobiology of Facial Nerve Repair and Regeneration
QUAN Shi-ming
GAO Zhi-qiang
摘要：Immunobiological study is a key to revealing the important basis of facial nerve repair and regeneration for both research and development of clinic treatments. The microenvironmental changes around an injuried facial motoneuron, i.e., the aggregation and expression of various types of immune cells and molecules in a dynamic equilibrium, impenetrate from the start to the end of the repair of an injured facial nerve. The concept of "immune microenvironment for facial nerve repair and regeneration", mainly concerns with the dynamic exchange between expression and regulation networks and a variaty of immune cells and immune molecules in the process of facial nerve repair and regeneration for the maintenance of a immune microenvironment favorable for nerve repair.Investigation on microglial activation and recruitment, T cell behavior, cytokine networks, and immunological cellular and molecular signaling pathways in facial nerve repair and regeneration are the current hot spots in the research on immunobiology of facial nerve injury. The current paper provides a comprehensive review of the above mentioned issues. Research of these issues will eventually make immunological interventions practicable treatments for facial nerve injury in the clinic.
机标关键词：facial nervenerve repairresearch and developmentnerve injuryimmune cells
分类号：R76(耳鼻咽喉科学)
资助基金：National "Tenth-Five" Scientific & Technological Problem-Tackling Project(2004BA720A18-01)Social Welfare Foundation of Scientific Research Institutes of Chinese Ministry of Science & Technology(2002DB40097)
论文发表日期：2006-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 107-115 )
英文信息