Vestibular-evoked myogenic potentials recorded from miniature pigs and rats

Li Ya; Zhang Yan; Qiu ShiWei; Yuan Na; Shi Xi; Qiao Yuehua; Shi-Ming Yang

摘要：Objective:To report vestibular evoked myogenic potentials from different recording sites (neck extensor or masseter muscles) in miniature pigs and rats. <br> Methods:Potentials were recorded using 1000 Hz tone bursts from the neck extensor muscle or masseter muscle in normal adult Bama miniature pigs and rats anesthetized with 3%pentobarbital sodium and Sumianxin II. <br> Results:At 80 dB SPL, the first positive wave (P wave) of VEMPs was recognizable in 58%of rats with a latency of 6.45 ± 0.23 ms and an amplitude of 1.45 ± 0.49 mV when recorded from the neck extensor muscle, and in 50% of rats with a latency of 6.38 ± 0.34 ms and an amplitude of 1.57 ± 0.35 mV when recorded from the masseter muscle. In miniature pigs, at the same stimulus intensity, P wave was recog-nizable in 58%of the animals with a latency of 7.65 ± 0.64 ms and an amplitude of 1.66 ± 0.34 mV when recorded from the neck extensor muscle, and in 50%of the animals with a latency of 7.65 ± 0.64 ms and an amplitude of 0.31 ± 0.28 mV when recorded from the masseter muscle. <br> Conclusion:VEMP can be induced from both neck extensor and masseter muscles in the miniature pig and rat. For a given species, the site of recording affects P wave induction rate and amplitude but not latency. Consistency and repeatability analysis suggests that the masseter muscle is a better recording site in miniature pigs while the cervical extensor is a better recording site in rats. For a given recording site, both latency and amplitude of the P wave are slightly greater in miniature pigs than in rats. <br> Copyright ? 2016, PLA General Hospital Department of Otolaryngology Head and Neck Surgery. Production and hosting by Elsevier (Singapore) Pte Ltd. This is an open access article under the CC BY-NC-ND license (