Evaluation of pure-tone audiometric protocols in vestibular schwannoma screening
Matej Vnencak1
Elina Huttunen2
Antti A.Aarnisalo2
Jussi Jero2
Katja Liukkonen2
Saku T.Sinkkonen2
1.Department of Otorhinolaryngology-Head and Neck Surgery,Turku University Hospital,Turku,Finland;Head and Neck Center,Otorhinolaryngology-Head and Neck Surgery,Helsinki University Hospital,And University of Helsinki,Helsinki,Finland2.Head and Neck Center,Otorhinolaryngology-Head and Neck Surgery,Helsinki University Hospital,And University of Helsinki,Helsinki,Finland
摘要：The objective was to evaluate the pure-tone audiogram-based screening protocols in VS diagnostics. We retrospectively analyzed presenting symptoms, pure tone audiometry and MRI finding from 246 VS patients and 442 controls were collected to test screening protocols (AAO-HNS, AMCLASS-A/B, Charing Cross, Cueva, DOH, Nashville, Oxford, Rule3000, Schlauch, Seattle, Sunderland) for sensitivity and specificity. Results were pooled with data from five other studies, and analysis of sensitivity, specificity and positive likelihood ratio (LR+) for each protocol was performed. Our results show that protocols with significantly higher sensitivity (AMCLASS-A/B, Nashville) show also significantly lowest specificity, and tend to have low association (positive likelihood ratio, LR+) to the VS. The highest LR+ was found for protocols AAO-HNS, Rule3000 and Seattle. In conclusions, knowing their properties, screening protocols are simple decision-making tools in VS diagnostic. To use the advantage of the highest sensitivity, protocols AMCLASS-A + B or Nashville can be of choice. For more reasonable approach, applying the protocols with high LR+(AAO-HNS, Rule3000, Seattle) may reduce the overall number of MRI scans at expense of only few primarily undiagnosed VS.
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论文发表日期：2021-09-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 138-143 )
英文信息