Peripheral vestibular system:Age-related vestibular loss and associated deficits
Jennifer coto1
Carmen L.Alvarez2
Ivette Cejas1
Brett M.Colbert3
Bonnie E.Levin4
Joshua Huppert1
Tatjana Rundek4
Carey Balaban5
Susan H.Blanton6
David J.Lee7
David Loewenstein8
Michael Hoffer1
Xue Zhong Liu1
1.University of Miami Miller School of Medicine,Department of Otolaryngology,Miami,FL,USA2.San Juan Bautista Medical School,Caguas,PR,USA3.University of Miami Miller School of Medicine,Department of Otolaryngology,Miami,FL,USA;Medical Scientist Training Program,University of Miami Miller School of Medicine,Miami,FL,USA4.University of Miami Miller School of Medicine,Department of Neurology and the Evelyn F.McKnight Brain Institute,Miami,FL,USA5.University of Pittsburgh,Departments of Otolaryngology,Neurobiology,Communication Sciences & Disorders,and Bioengineering,Pittsburgh,PA,USA6.University of Miami Miller School of Medicine,Dr.John T.Macdonald Department of Human Genetics,Miami,FL,USA7.University of Miami Miller School of Medicine,Department of Public Health Sciences,Miami,FL,USA8.University of Miami Miller School of Medicine,Department of Psychiatry and Behavioral Sciences,Miami,FL,USA
摘要：Given the interdependence of multiple factors in age-related vestibular loss (e.g.,balance,vision,cognition),it is important to examine the individual contributions of these factors with ARVL.While the relationship between the vestibular and visual systems has been well studied (Bronstein et al.,2015),little is known about the association of the peripheral vestibular system with neurodegenerative dis-orders (Cronin et al.,2017).Further,emerging research developments implicate the vestibular system as an opportunity for examining brain function beyond balance,and into other areas,such as cognition and psychological functioning.Additionally,the bidirectional impact of psychological functioning is under-studied in ARVL.Recognition of ARVL as part of a multifaceted aging process will help guide the development of integrated interventions for patients who remain at risk for decline.In this review,we will discuss a wide variety of characteristics of the peripheral vestibular system and ARVL,how it relates to neurodegenerative diseases,and correlations between ARVL and balance,vision,cognitive,and psy-chological dysfunction.We also discuss clinical implications as well as future directions for research,with an emphasis on improving care for patients with ARVL.
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论文发表日期：2021-12-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 258-265 )
英文信息