A genome-wide association study about presbycusis and brain cortical structure:Neu-roimaging traits from a Mendelian randomization study
Zhencheng Gao
Jingxian Wang
Xingmei Wei
Yongxin Li
Department of Otorhinolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Beijing,China
摘要：Objectives:The causal association between presbycusis and changes in cerebral cortex structure was evaluated through Mendelian randomization(MR).Methods:Presbycusis data,serving as the exposure trait,was analyzed using data from the ninth release of the FinnGen biobank.Genome-wide association study(GWAS)datasets for cortical surface area(SA)and thickness(TH)were sourced from the ENIGMA Consortium,whereas cortical volume(V)GWAS data came from the UK Biobank.The inverse-variance weighted(IVW)approach was adopted as the principal analytical method.To ensure robustness,sensitivity analyses were systematically implemented to evaluate potential heterogeneity and pleiotropic effects.Results:Following rigorous filtering through IVW and sensitivity analyses,eleven robust MR associations emerged,offering preliminary evidence for a causal link between presbycusis and cortical architecture,including frontal pole SA with global weighted(GW)(β=1.858 mm2,P=0.004)and without GW(β=1.778 mm2,P=0.012),pars orbitalis SA with GW(β=2.717 mm2,P=0.042),transverse temporal SA with GW(β=2.349 mm2,P=0.033),pars orbitalis TH with GW(β=-0.009 mm,P=0.008)and without GW(β=-0.011 mm,P=0.008),rostral middle frontal TH with GW(β=-0.005 mm,P=0.020)and without GW(β=-0.007 mm,P=0.012),precuneus TH without GW(β=-0.006 mm,P=0.049),left hippocampus V(β=-12.296 mm3,P=0.033)and right hippocampus V(β=-11.991 mm3,P=0.049).Conclusion:From a genetic standpoint,our findings indicate region-specific neuroanatomical modifications in presbycusis patients,supporting the notion of neurodegenerative or adaptive alterations in brain structure from a genetic perspective.
机标关键词：associationstructurestudytraitsbrainfromaboutcortical
论文发表日期：2025-10-30
在线出版日期：2025-11-27（本平台首次上网日期，不代表文献的发表时间）
页数：8( 245-252 )
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