1Outcomes in octogenarians undergoing percutaneous coro-nary intervention:nationwide data from the Netherlands Heart RegistrationNousjka PA Vranken，Sanne Janssen，Tobias FS Pustjens，Romi Michon，Lineke Derks，Arnoud WJ van't Hof，Saman Rasoul，on behalf of the PCI and Cardiothoracic Surgery Registration Committee of the Netherlands Heart RegistrationRESEARCH ARTICLE1-8
2Frailty as a risk factor for hospitalization and mortality in older adults admitted to a chronic heart failure hospital program before and during the COVID-19 pandemicJhovana Carhuallanqui-Bastidas，Eleazar Guino Mejía-Sánchez，Willy Ramos，María Lu-isa Huamán-Severino，José Luis Carhuallanqui-Bastidas，Jhon Alex Zeladita-Huaman，Laryn SmithRESEARCH ARTICLE9-16
3Utility of the Vulnerable Elders Survey-13(VES-13)in detect-ing frailty and predicting prognosis in heart failure outpati-entsThaïs Roig，Elisabet Zamora，Josep Lupón，Beatriz González，Ana Pulido，Eva Crespo，Patricia Velayos，Carmen Rivas，Violeta Díaz，Yolanda López，Andrea Borrel-las，Mar Domingo，María Ruiz，Pau Codina，Evelyn Santiago-Vacas，Miquel À Mas，Ramón Miralles，Antoni Bayes-GenisRESEARCH ARTICLE17-26
4CT-derived fractional flow reserve combined with atherosclero-tic extent to determine long-term outcomes in diabetic pati-ents with coronary artery diseaseZhi-Qiang WANG，Zhen-Nan LI，Zhi-Hui HOU，Bin LURESEARCH ARTICLE27-35
5Evaluating the association between oral microbiota and cardiovascular diseases:evidence from Mendelian rando-mization analysisSi-Da QIN，Yi-Wen ZHANG，Jing-Zhi WANGRESEARCH ARTICLE36-44
6From ancient herb to modern miracle:an in-depth analysis of the cardioprotective effects of artemisinin and its deriva-tivesHao-Shuang LI，Shu-Rong LI，Wen-Jue LIU，Yuan ZHANG，Rui WU，Xu-Yang CUI，Jia-Zheng SUN，You-Wei MA，Ying ZHAOREVIEW45-64
7A case report with the progression from atrial fibrillation to complete AV block,heart failure and electrical stormShi-Xing LI，Xiang-Min SHI，Jian LI，Chuang ZHANGLETTER TO THE EDITOR65-68
