1Understanding metabolic reprogramming in tumor microenvironmentShaokun Shu，Ying Xu，Qimin ZhanEditorial111-113
2TahcoRoll:fast genomic signature profiling via thinned automaton and rolling hashChelsea J.-T.Ju，Jyun-Yu Jiang，Ruirui Li，Zeyu Li，Wei WangResearch Article114-125
3A commentary on:"A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells"-tumor microenvironment:the Achilles heel of cancerJingtao Wei，Zhaode Bu，Jiafu JiCommentary126-128
4Polygenic risk scores:the future of cancer risk prediction,screening,and precision preventionYuzhuo Wang，Meng Zhu，Hongxia Ma，Hongbing ShenReviews129-149
6Digital tongue image analyses for health assessmentJiacheng Xie，Congcong Jing，Ziyang Zhang，Jiatuo Xu，Ye Duan，Dong XuReviews172-198
7Connections between metabolism and epigenetic modifications in cancerGuangchao Wang，Jingdong J.HanReviews199-221
8Tumor-associated macrophages,dendritic cells,and neutrophils:biological roles,crosstalk,and therapeutic relevanceMingyi Shen，Yanhua Du，Youqiong YeReviews222-243
9Nano drug delivery systems improve metastatic breast cancer therapyRunqi Zhu，Tianqun Lang，Qi Yin，Yaping LiReviews244-274
