2Report on cardiovascular health and diseases in China 2021:an updated summaryThe Writing Committee of the Report on Cardiovascular Health and Diseases in China，Sheng-Shou HUSPECIAL ARTICLE399-430
3Down-regulation of the Smad signaling by circZBTB46 via the Smad2-PDLIM5 axis to inhibit type Ⅰ collagen expressionJing YU，Wen-Zhao YAN，Xin-Hua ZHANG，Bin ZHENG，Wen-Sen PAN，Zhan YANG，Hong ZHANG，Zi-Yuan NIE，Ying MA，Yang BAI，Long ZHANG，Dan-Dan FENG，Jin-Kun WENRESEARCH ARTICLE431-447
4Nocturnal hypertension and riser pattern are associated with heart failure rehospitalization in patients with heart failure with preserved ejection fractionGang HUANG，Xiao-Han LIU，Yue ZHANG，Yu-Xin ZHU，Yun HE，Tian-Bo WANG，Zhen ZHANG，Jun-Bo XURESEARCH ARTICLE448-458
5Outcomes of catheter-directed thrombolysis versus systemic thrombolysis in the treatment of pulmonary embolism:a meta-analysisHuang-Tai MIAO，Ying LIANG，Xiao-Ying LI，Xiao WANG，Hui-Juan ZUO，Zhe-Chun ZENG，Shao-Ping NIERESEARCH ARTICLE459-468
6Target versus sub-target dose of renin-angiotensin system inhibitors on survival in elderly patients with heart failure with reduced ejection fraction:a systematic review and meta-anal-ysisLong-Kun SUN，Jing KONG，Xiao-Wei YANG，Jing WANG，Peng-Fei ZHANGRESEARCH ARTICLE469-478
7Iatrogenic pneumopericardium after therapeutic pericardio-centesis for pericardial effusion:a case reportYang-Yang ZHU，Ting-Ting WANG，Xiao-Na XU，Jing-Yue XU，Hua-Ying FU，Guang-Ping LI，Tong LIU，Chang-Le LIULETTER TO THE EDITOR479-482
8Unraveling the mechanisms of a giant coronary sinusMichail Kyrtsopoulos，Apostolos Galatas，Anastasios KartasLETTER TO THE EDITOR483-484
