2The complex interplay between aging and cancer:unraveling the cluesZhenqwei Xie，Qimin ZhanEditorial2-4
3Nanotechnology-based delivery systems to overcome drug resistance in cancerHarsh Patel，Jiaxin Li，Letao Bo，Riddhi Mehta，Charles R.Ashby，Shanzhi Wang，Wei Cai，Zhe-Sheng ChenReviews5-30
4The role of Down syndrome cell adhesion molecule in Down syndromeTy Hergenreder，Tao Yang，Bing YeReviews31-41
5Evidence-based rehabilitation medicine:definition,foundation,practice and developmentJinlong Zhang，Chengqi HeReviews42-54
6Therapeutic robots for post-stroke rehabilitationRonghua Hong，Bingyu Li，Yunjun Bao，Lingyu Liu，Lingjing JinReviews55-67
7The new era of cardiovascular research:revolutionizing cardiovascular research with 3D models in a dishYuan Yang，Hao Yang，Fedir N.Kiskin，Joe Z.ZhangReviews68-85
