1Acute heart failure in the elderly:setting related differences in clinical features and managementFrancesco Orso，Alessandra Pratesi，Andrea Herbst，Anna Chiara Baroncini，Francesca Bacci，Gabriele Ciuti，Andrea Berni，Camilla Tozzetti，Carlo Nozzoli，Alberto Moggi Pignone，Loredana Poggesi，Luciano Gabbani，Mauro Di Bari，Francesco Fattirolli，Massimo Milli，Andrea Ungar，Niccolò Marchionni，Samuele BaldasseroniRESEARCH ARTICLE407-415
2Epidemiology,etiology,and outcomes of in-hospital cardiac arrest in LebanonAhmed Eltarras，Youssef Jalloul，Ola Assaad，Michael Bejjani，Yara Yammine，Nina Khatib，Abdallah Rebeiz，Mazen El Sayed，Marwan RefaatRESEARCH ARTICLE416-425
3Downregulation of miR-181a-5p alleviates oxidative stress and inflammation in coronary microembolization-induced myocardial damage by directly targeting XIAPYou ZHOU，Man-Yun LONG，Zhi-Qing CHEN，Jun-Wen HUANG，Zhen-Bai QIN，Lang LIRESEARCH ARTICLE426-439
4Effects of sodium-glucose cotransporter 2 inhibitors on cardiovascular outcomes in elderly patients with comorbid coronary heart disease and diabetes mellitusHu XU，Wen-Zhe CAO，Yong-Yi BAI，Rui-Hua CAO，Lei TIAN，Feng CAO，Li FANRESEARCH ARTICLE440-448
5Severe bleeding following off-pump coronary artery bypass grafting:predictive factors and risk modelYu LIU，Xing WANG，Zi-Ying CHEN，Wen-Li ZHANG，Lin GUO，Yong-Quan SUN，Hong-Zhan CUI，Ji-Qiang BU，Jian-Hui CAIRESEARCH ARTICLE449-461
6Cardiovascular risk and aging:the need for a more comprehensive understandingLjiljana Trtica Majnari(c)，Zvonimir Bosni(c)，Tomislav Kurevija，Thomas WittlingerPERSPECTIVE462-478
7Frailty in patients undergoing transcatheter aortic valve replacement:from risk scores to frailty-based managementAndreas Tzoumas，Damianos G.Kokkinidis，Stefanos Giannopoulos，George Giannakoulas，Leonidas Palaiodimos，Dimitrios V Avgerinos，Polydoros N Kampaktsis，Robert T.FaillacePERSPECTIVE479-486
8A new sequential two-stent strategy for treating true distal left main trifurcation lesionYu-Xiang DAI，Chen-Guang LI，Jia HUANG，Ren-De XU，Shu-Fu CHANG，Hao LU，Dao-Yuan REN，Lei GE，Ju-Ying QIAN，Feng ZHANG，Jun-Bo GELETTER TO THE EDITOR487-491
9A case of applying left bundle branch pacing combined with atrioventricular node ablation to treat atrial fibrillation-induced heart failureLahati HA，Li-Yun HE，Lei LI，Jiang-Li HAN，Shu-Wang LIU，Yuan ZHANG，Wei XU，Wei GAOLETTER TO THE EDITOR492-497
10Partial closure with a self-made fenestrated device of secundum atrial septal defect with severe pulmonary artery hypertension in adultsTullio Tesorio，Luigi Salemme，Sebastiano Verdoliva，Marco Ferrone，Paola Tesorio，Eustaquio Maria OnoratoLETTER TO THE EDITOR498-504
