1Editorial commentary on the special issue of CRISPR Trends in Biomedical ResearchHongbing ShenEDITORIAL COMMENTARY75
2Designing and generating a mouse model: frequently asked questionsChannabasavaiah B.Gurumurthy，Thomas L.Saunders，Masato OhtsukaREVIEW ARTICLES76-90
3Harnessing CRISPR-Cas system diversity for gene editing technologiesAlexander McKay，Gaetan BurgioREVIEW ARTICLES91-106
4Base editing: a brief review and a practical exampleDongwook C.Choe，Kiran MusunuruREVIEW ARTICLES107-114
5Therapeutic gene editing strategies using CRISPR-Cas9 for the β-hemoglobinopathiesJames B.Papizan，Shaina N.Porter，Akshay Sharma，Shondra M.Pruett-MillerREVIEW ARTICLES115-134
6Genome engineering technologies in rabbitsJun Song，Jifeng Zhang，Jie Xu，Minerva Garcia-Barrio，Y.Eugene Chen，Dongshan YangREVIEW ARTICLES135-147
7Progress and challenges in CRISPR-mediated therapeutic genome editing for monogenic diseasesColin T.Konishi，Chengzu LongREVIEW ARTICLES148-162
8A transgenic pig model expressing a CMV-ZsGreen1 reporter across an extensive array of tissuesAmy T.Desaulniers，Rebecca A.Cederberg，Elizabeth P.Carreiro，Channabasavaiah B.Gurumurthy，Brett R.WhiteORIGINAL ARTICLE163-173
9Generating a CRISPR knockout mouse through a strong premature termination codon: a cautionary taleQing Rex Lyu，Peng Yao，Joseph M.MianoLETTER TO THE EDITOR174-178
